Intravenous immunoglobulin G (IVIG) is now the leading product obtained by fractionation of
human plasma. It is the standard replacement therapy in primary and acquired humoral …

Oral immunoglobulin (Ig) preparations are prime examples of medicinal nutrition from
natural sources. Plasma products containing Ig have been used for decades in animal feed …

Neutralizing antibodies against factor VIII (FVIII) remain the major complication in the
replacement therapy of hemophilia A patients. To better understand the evolution of these …

Plasma‐derived intravenous immunoglobulin (IVIG) preparations have been successfully
applied for the prophylactic prevention of infectious diseases in immunodeficient patients. In …

Despite the paradigm that carbohydrates are T cell–independent antigens, isotype-switched
glycan-specific immunoglobulin G (IgG) antibodies and polysaccharide-specific T cells are …

Objectives To evaluate the outcomes of hospitalized patients in two intensive care units
(ICU) treated with intravenous immunoglobulin (IVIg) added to standard-of-care therapy. The …

Significant progress has been made in the elucidation of human antibody repertoires.
Furthermore, non-canonical functions of antibodies have been identified that reach beyond …

The human IgG repertoire contains endogenous antibodies against beta amyloid (Aβ) that
may be relevant to the pathogenesis and treatment of Alzheimer's disease. There have been …

The mechanisms underlying the modulation of Natural Killer (NK) cell functions by
intravenous immunoglobulin (IVIg) are poorly understood. Using an ex vivo whole blood …

IgG molecules are exposed on a regular basis to acidic conditions during immunoaffinity
purification procedures, as well as during the production of some therapeutic …