We explored trans-and cis-2-aminocycloheptanecarboxylic acid (ACHpC) as potential
building blocks for helical foldamers. trans-ACHpC does not show sufficient folding …

α, β2, 3-Disteroisomeric foldamers of general formula Boc (S-Ala-β-2 R, 3 R-Fpg) nOMe or
Boc (S-Ala-β-2 S, 3 S-Fpg) nOMe were prepared from both enantiomers of syn H-2-(2-F …

α/β-Peptides with alternating α-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-
ACHC) residues adopt 11/9-helical conformations, the folding propensity of which …

The present study is aimed at the design and synthesis of peptides with hybrid helix-turn-
helix (HTH) motif and their conformational analysis (NMR, MD, and CD studies). The …

The study describes synthesis of (S)-and (R)-oxetane-β 3-amino acid (β 3-Oaa) monomers
from diacetone glucose (DAG). The oxetane ring is prepared by a nucleophilic cyclization …

The present study describes the solid‐state conformation of αβ hybrid peptides, Boc‐Leu‐
β3, 3‐Ac6c‐OH, P1; Boc‐Leu‐β3, 3‐Ac6c‐Leu‐β3, 3‐Ac6c‐OMe, P2; and Boc‐Leu‐β3, 3 …

The 11/9-helix is among the most stable and non-traditional helical structures for α/β-
peptides with alternating residue types. The effect of side chain groups of α-residues and β3 …

cis-2-Aminocyclohex-4-enecarboxylic acid (cis-ACHE) is a conformationally constrained β-
amino acid. We showed that the conformational preference of a cis-ACHE residue is similar …

Cyclic β2, 3-amino acids though have been extensively used in foldamer designs, their
acyclic analogues have received less attention. In view of strong backbone constraints …

Enantiopure β-aminocyclooctenenitriles, as precursors of β-amino acids and β-lactams,
were synthesized from a readily available chloroalkene nitrile and (S)-methylbenzylamine …