G protein–coupled receptors engage both G proteins and β-arrestins, and their coupling can
be biased by ligands and mutations. Here, to resolve structural elements and mechanisms …

Molecular dynamics simulation is the most popular computational technique for investigating
the structural and dynamical behaviour of proteins, in search of the molecular basis of their …

Abstract The MC4R, a GPCR, has long been a major target for obesity treatment. As the
most well‐studied melanocortin receptor subtype, the evolutionary knowledge pushes the …

Angiotensin II (AngII) is a peptide hormone that plays a key role in regulating blood
pressure, and its interactions with the G protein-coupled receptors, AngII type-1 receptor (AT …

While orthosteric ligands of the angiotensin II (AngII) type 1 receptor (AT1R) are available for
clinical and research applications, allosteric ligands are not known for this important G …

Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular
diseases. Compared with orthosteric ligands, allosteric modulators attract considerable …

Abstract Angiotensin II receptors, Type 1 (AT1R) and Type 2 (AT2R) are 7TM receptors that
play critical roles in both the physiological and pathophysiological regulation of the …

G protein-coupled receptors (GPCRs) represent the largest membrane protein family and a
significant target class for therapeutics. Receptors from GPCRs' largest class, class A …

Homeostasis in the cardiovascular system is maintained by physiological functions of the
Renin Angiotensin Aldosterone System (RAAS). In pathophysiological conditions, over …

Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated
ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis …