The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of
mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal …

Background In patients with acquired aplastic anemia, destruction of hematopoietic cells by
the immune system leads to pancytopenia. Patients have a response to immunosuppressive …

Genetic alterations, including mutations and copy-number alterations, are central to the
pathogenesis of myelodysplastic syndromes and related diseases (myelodysplasia), but …

Purpose Clonal hematopoiesis of indeterminate potential (CHIP) occurs in the blood of
approximately 20% of older persons. CHIP is linked to an increased risk of hematologic …

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders
with an inherent tendency for leukemic transformation. Diagnosis is currently based on the …

Clonal hematopoiesis of indeterminate potential (CHIP) occurs in an age-related manner
and associates with an increased risk of hematologic cancer, atherosclerotic disease, and …

Abstract Changes in chromatin structure mediated by ATP-dependent nucleosome
remodelers and histone modifying enzymes are integral to the process of gene regulation …

BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell
differentiation and body structure development and takes part in the noncanonical polycomb …

Cytogenetic diagnostics play a crucial role in risk stratification and classification of myeloid
malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) …