More than a decade ago, the question was raised by Sweeney if aziridines are epoxides'
ugly cousins? 1 The overview on the biological properties, synthetic accessibility, and useful …

Adenosylcobalamin (coenzyme B12) serves as the cofactor for a group of enzymes that
catalyze unusual rearrangement or elimination reactions. The role of the cofactor as the …

Vitamin B12 (cobalamin) is required for proper red blood cell formation, neurologic function,
and DNA synthesis. Cobalamins in solutions are light sensitive, but no comprehensive study …

Radical cyclizations are essential reactions in the biosynthesis of secondary metabolites
and the chemical synthesis of societally valuable molecules. In this review, we highlight the …

Aminomutases carry out the chemically challenging exchange of a hydrogen atom and an
amine substituent present on neighboring carbon atoms. In recent years, aminomutases …

The PLP-dependent l-arginine hydroxylase/deaminase MppP from Streptomyces
wadayamensis (SwMppP) is involved in the biosynthesis of l-enduracididine, a …

d-Ornithine 4, 5-aminomutase (OAM) from Clostridium sticklandii converts d-ornithine to 2, 4-
diaminopentanoic acid by way of radical propagation from an adenosylcobalamin (AdoCbl) …

We present here an energetic and atomistic description of how d-ornithine 4, 5-
aminomutase (OAM), an adenosylcobalamin (AdoCbl; coenzyme B12)-dependent …

Several anaerobic bacterial species, including the Gram-negative oral bacterium
Fusobacterium nucleatum, ferment lysine to produce butyrate, acetate, and ammonia. The …

Pyridoxal 5′-phosphate (PLP)-dependent enzymes are found ubiquitously in nature and
are involved in a variety of biological pathways, from natural product synthesis to amino acid …