The structural spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) plays an essential role in infection and is an important target for neutralizing …

Collagen, the most abundant extracellular matrix protein in animal kingdom belongs to a
family of fibrous proteins, which transfer load in tissues and which provide a highly …

In recent decades, collagen is one of the most versatile biomaterials used in biomedical
applications, mostly due to its biomimetic and structural composition in the extracellular …

The extracellular matrix (ECM) is a meshwork of both structural and functional proteins
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …

Biologic scaffolds are derived from mammalian tissues, which must be decellularized to
remove cellular antigens that would otherwise incite an adverse immune response …

Regenerative medicine approaches based on decellularized extracellular matrix (ECM)
scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural …

Current clinical treatment strategies for the bypassing of small diameter (< 6 mm) blood
vessels in the management of cardiovascular disease frequently fail due to a lack of suitable …

The reconstruction of musculoskeletal defects is a constant challenge for orthopaedic
surgeons. Musculoskeletal injuries such as fractures, chondral lesions, infections and tumor …

Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions.
However, a dearth of available donor organs for transplantation leads to the death of …

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …