The focus of this review is a group of structures/organelles collectively known as
extracellular vesicles (EVs) that are secreted by most, if not all, cells, varying from …

T. cruzi has a complex life cycle involving four developmental stages namely, epimastigotes,
metacyclic trypomastigotes, amastigotes and bloodstream trypomastigotes. Although …

Extracellular vesicles (EVs) act as cell communicators and immune response modulators
and may be employed as disease biomarkers and drug delivery systems. In infectious …

Trypanosoma cruzi, the protozoa that causes Chagas disease in humans, is transmitted by
insects from the Reduviidae family. The parasite has developed the ability to change the …

Host cell invasion by Trypanosoma cruzi metacyclic trypomastigote (MT) is mediated by MT‐
specific surface molecule gp82, which binds to a still unidentified receptor, inducing …

To complete its life cycle within the mammalian host, Trypanosoma cruzi, the agent of
Chagas' disease, must enter cells. Trypomastigotes originating from the insect vector …

Trypanosoma cruzi, the protozoan parasite causative agent of Chagas disease, affects
about seven million people worldwide, representing a major global public health concern …

Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector
proteins to forward the signal downstream in several cellular pathways. Actin cytoskeleton …

Trypanosoma cruzi is the causative protozoan of Chagas' Disease, a neglected tropical
disease that affects 6− 7 million people worldwide. Interaction of the parasite with the host …

Cell invasion by Trypanosoma cruzi extracellular amastigotes (EAs) relies significantly upon
the host cell actin cytoskeleton. In past decades EAs have been established as a reliable …