Micelles and nanoparticles for ultrasonic drug and gene delivery

GA Husseini, WG Pitt - Advanced drug delivery reviews, 2008 - Elsevier
Drug delivery research employing micelles and nanoparticles has expanded in recent years.
Of particular interest is the use of these nanovehicles that deliver high concentrations of …

Systemic delivery of oncolytic viruses: hopes and hurdles

MS Ferguson, NR Lemoine, Y Wang - Advances in virology, 2012 - Wiley Online Library
Despite recent advances in both surgery and chemoradiotherapy, mortality rates for
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …

PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives

M Alvi, A Yaqoob, K Rehman, SM Shoaib, MSH Akash - AAPS Open, 2022 - Springer
Research on cancer treatment is always of great importance because of the extensive and
difficult treatment options and side effects of chemotherapeutic agents. Due to this, novel …

Gene therapy progress and prospects: ultrasound for gene transfer

CMH Newman, T Bettinger - Gene therapy, 2007 - nature.com
Ultrasound exposure (USE) in the presence of microbubbles (MCB)(eg contrast agents used
to enhance ultrasound imaging) increases plasmid transfection efficiency in vitro by several …

Mechanism of intracellular delivery by acoustic cavitation

RK Schlicher, H Radhakrishna, TP Tolentino… - Ultrasound in medicine …, 2006 - Elsevier
Using conditions different from conventional medical imaging or laboratory cell lysis,
ultrasound has recently been shown to reversibly increase plasma membrane permeability …

Targeted therapy of breast tumor by PLGA-based nanostructures: The versatile function in doxorubicin delivery

TS Dongsar, TT Dongsar, N Molugulu… - Environmental …, 2023 - Elsevier
Breast carcinoma is a molecularly diverse illness, and it is among the most prominent and
often reported malignancies in female across the globe. Surgical intervention …

PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications

X Shen, T Li, X Xie, Y Feng, Z Chen, H Yang… - … in Bioengineering and …, 2020 - frontiersin.org
Intelligent drug delivery systems based on nanotechnology have been widely developed
and investigated in the field of nanomedicine since they were able to maximize the …

Sonoporation, drug delivery, and gene therapy

HD Liang, J Tang, M Halliwell - Proceedings of the Institution …, 2010 - journals.sagepub.com
Ultrasound is a very effective modality for drug delivery and gene therapy because energy
that is non-invasively transmitted through the skin can be focused deeply into the human …

Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo

OV Chumakova, AV Liopo, VG Andreev, I Cicenaite… - Cancer letters, 2008 - Elsevier
The goal of this study was to enhance gene delivery and tumor cell transfection in vivo by
using a combination of ultrasonication with complex nanoparticles consisting of two types of …

Effective gene delivery with novel liposomal bubbles and ultrasonic destruction technology

R Suzuki, T Takizawa, Y Negishi, N Utoguchi… - International journal of …, 2008 - Elsevier
From the viewpoint of safety, non-viral vector systems represent an attractive gene delivery
system for gene therapy. However, the transfection efficiency of non-viral vectors in vivo is …