The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …

Aversive events rapidly and potently excite certain dopamine neurons in the ventral
tegmental area (VTA), promoting phasic increases in the medial prefrontal cortex and …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

Rationale Research on adolescence and drug abuse increased substantially in the past
decade. However, drug-addiction-related behaviors following stressful experiences during …

Background Although recent studies provide insight into the molecular mechanisms of the
effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their …

Elevations in glucocorticoids that result from environmental stressors can have programming
effects on brain structure and function when the exposure occurs during sensitive periods …

There is a need for innovation with respect to therapeutics in psychiatry. Available evidence
indicates that the trace amine-associated receptor 1 (TAAR1) agonist SEP-363856 is …

Our ability to develop the cognitive strategies required to deal with daily-life stress is
regulated by region-specific neuronal networks. Experimental evidence suggests that …

Repeated exposure to stress during childhood is associated with increased risk for
neuropsychiatric illness, substance use disorders and other behavioral problems in …