Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus
infection has been known for decades. However, most of the studies characterizing this …

Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger
triggering an interferon response. cGAMP is generated from GTP and ATP by cytoplasmic …

Interactions between noncoding RNAs and chromatin proteins play important roles in gene
regulation, but the molecular details of most of these interactions are unknown. Using …

Codon bias has been implicated as one of the major factors contributing to mRNA stability in
several model organisms. However, the molecular mechanisms of codon bias on mRNA …

RNA-editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to
inosines in structured RNAs. Inosines are read as guanosines by most cellular machineries …

Abstract Adenosine-to-inosine (A-to-I) editing, mediated by the ADAR enzymes, diversifies
the transcriptome by altering RNA sequences. Recent studies reported global changes in …

Mitochondrial fission is important for organelle transport, inheritance, and turnover, and
alterations in fission are seen in neurological disease. In mammals, mitochondrial fission is …

Although the route to generate microRNAs (miRNAs) is often depicted as a linear series of
sequential and constitutive cleavages, we now appreciate multiple alternative pathways as …

Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA
(ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites …