For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most
common neurodegenerative disorder that causes irreversible blindness worldwide. It is …

Retinal organoids are three-dimensional structures derived from human pluripotent stem
cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving …

Although an increasing number of disease genes have been identified, the exact cellular
mechanisms of retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) …

Retinal ganglion cells (RGCs) serve as the connection between the eye and the brain, with
this connection disrupted in glaucoma. Numerous cellular mechanisms have been …

Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of
glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although …

Recent advances in stem cell engineering have led to an explosion in the use of organoids
as model systems for studies in multiple biological disciplines. Together with breakthroughs …

Abstract Three-dimensional (3D) retinal organoids, in vitro tissue structures derived from self-
organizing cultures of differentiating human embryonic stem cells or induced pluripotent …

Recent advances in high throughput single-cell RNA sequencing (scRNA-seq) technology
have enabled the simultaneous transcriptomic profiling of thousands of individual cells in a …

Glaucoma, one of the most common causes of blindness in developing countries today,
involves a progressive loss of neural cells in the optic nerve that leads to progressive …