Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment
of epilepsy and bipolar disorder. Adverse effects of valproic acid are rare, but hepatotoxicity …

The large number of different syndromes and seizure types together with an interindividual
variable response to antiepileptic drugs (AEDs) make the treatment of epilepsy challenging …

Aim: The aim of this study was to evaluate the association of genetic variants in the major
genes involved in carbamazepine (CBZ) metabolism and transport with its pharmacokinetics …

Objective To determine whether common polymorphisms in CACNA1G, CACNA1H,
CACNA1I, and ABCB1 are associated with differential short‐term seizure outcome in …

ABCB1 Gene C3435T Polymorphism and Drug Resistance in Epilepsy: Evidence Based on
8604 Subjects - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Objective Previous studies reported the associations between the ATP-binding cassette sub-
family B member 1 (ABCB1, also known as MDR1) polymorphisms and their haplotypes with …

Valproic acid (VPA) is a first-line anti-epileptic drug that is used in the treatment of
generalized and partial seizures. Gene variants had been proved to influence the …

Purpose Carbamazepine (CBZ) is used as the first line of treatment of Complex Partial
Seizures (CPS) in the Epilepsy Clinic, Neurology Department of Kuala Lumpur Hospital …

Although the Pgp efflux transport protein is overexpressed in resected tissue of patients with
epilepsy, the presence of polymorphisms in MDR1/ABCB1 and MRP2/ABCC2 in patients …

Purpose This study aims to evaluate the associations between genetic polymorphisms and
the effect of sodium valproate (VPA) therapy in children with generalized seizures. Methods …