The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”, referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …
Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to …
We review the status of protein-based molecular electronics. First, we define and discuss fundamental concepts of electron transfer and transport in and across proteins and …
C Léger, P Bertrand - Chemical Reviews, 2008 - ACS Publications
This review regards the use of dynamic electrochemistry to study the mechanism of redox enzymes, with exclusive emphasis on the configuration where the protein is adsorbed onto …
E Schneider, DS Clark - Biosensors and Bioelectronics, 2013 - Elsevier
Cytochrome P450s (CYPs) are a large family of heme-containing monooxygenase enzymes involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …
Redox enzymes have tremendous potential as catalysts for preparative organic chemistry. Their usually high selectivity, paired with their catalytic efficiency under mild reaction …
The design of drugs from natural products is a re-emerging area due to the need for bioactive compounds. The exploitation of natural products and their derivatives obtained by …
Monooxygenases are promising catalysts because they in principle enable the organic chemist to perform highly selective oxyfunctionalisation reactions that are otherwise difficult …
C Gutiérrez-Sánchez, M Pita… - Journal of the …, 2012 - ACS Publications
Direct electron transfer (DET) reactions between redox enzymes and electrodes can be maximized by oriented immobilization of the enzyme molecules onto an electroactive …