Electrochemical transformations catalyzed by cytochrome P450s and peroxidases

N Kumar, J He, JF Rusling - Chemical Society Reviews, 2023 - pubs.rsc.org
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …

Structure and chemistry of cytochrome P450

IG Denisov, TM Makris, SG Sligar… - Chemical reviews, 2005 - ACS Publications
The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”,
referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …

Methylxanthine drug monitoring with wearable sweat sensors

LC Tai, W Gao, M Chao, M Bariya, QP Ngo… - Advanced …, 2018 - Wiley Online Library
Drug monitoring plays crucial roles in doping control and precision medicine. It helps
physicians tailor drug dosage for optimal benefits, track patients' compliance to …

Protein bioelectronics: A review of what we do and do not know

CD Bostick, S Mukhopadhyay, I Pecht… - Reports on Progress …, 2018 - iopscience.iop.org
We review the status of protein-based molecular electronics. First, we define and discuss
fundamental concepts of electron transfer and transport in and across proteins and …

Direct electrochemistry of redox enzymes as a tool for mechanistic studies

C Léger, P Bertrand - Chemical Reviews, 2008 - ACS Publications
This review regards the use of dynamic electrochemistry to study the mechanism of redox
enzymes, with exclusive emphasis on the configuration where the protein is adsorbed onto …

Cytochrome P450 (CYP) enzymes and the development of CYP biosensors

E Schneider, DS Clark - Biosensors and Bioelectronics, 2013 - Elsevier
Cytochrome P450s (CYPs) are a large family of heme-containing monooxygenase enzymes
involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …

Biocatalytic redox reactions for organic synthesis: nonconventional regeneration methods

F Hollmann, IWCE Arends, K Buehler - ChemCatChem, 2010 - Wiley Online Library
Redox enzymes have tremendous potential as catalysts for preparative organic chemistry.
Their usually high selectivity, paired with their catalytic efficiency under mild reaction …

Natural compounds as pharmaceuticals: the key role of cytochromes P450 reactivity

G Di Nardo, G Gilardi - Trends in Biochemical Sciences, 2020 - cell.com
The design of drugs from natural products is a re-emerging area due to the need for
bioactive compounds. The exploitation of natural products and their derivatives obtained by …

The oxygen dilemma: a severe challenge for the application of monooxygenases?

D Holtmann, F Hollmann - ChemBioChem, 2016 - Wiley Online Library
Monooxygenases are promising catalysts because they in principle enable the organic
chemist to perform highly selective oxyfunctionalisation reactions that are otherwise difficult …

Gold nanoparticles as electronic bridges for laccase-based biocathodes

C Gutiérrez-Sánchez, M Pita… - Journal of the …, 2012 - ACS Publications
Direct electron transfer (DET) reactions between redox enzymes and electrodes can be
maximized by oriented immobilization of the enzyme molecules onto an electroactive …