Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

The neurotrophins mediate diverse actions in the developing peripheral and central nervous
systems. They are initially synthesized as precursor forms, or proneurotrophins, that are …

The sequencing of the Strongylocentrotus purpuratus genome provides a unique
opportunity to investigate the function and evolution of neural genes. The neurobiology of …

Neurons of the peripheral nervous system have long been known to require survival factors
to prevent their death during development. But why they selectively become dependent on …

The Cambrian explosion was a unique animal radiation~ 540 million years ago that
produced the full range of body plans across bilaterians. The genetic mechanisms …

The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects
multiple processes in the brain, including neuronal survival and neurogenesis during …

The vertebrate peripheral nervous system (PNS) originates from neural crest and placodes.
While its developmental origin is the object of intense studies, little is known concerning its …

Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been
found. Neurotrophins are the main vertebrate secreted signalling molecules that link …

Vertebrate cranial placodes are crucial contributors to the vertebrate cranial sensory
apparatus. Their evolutionary origin has attracted much attention from evolutionary and …

The vertebrate brain is highly complex with millions to billions of neurons. During
development, the neural plate border region gives rise to the neural crest, cranial placodes …