[HTML][HTML] Genetics and SUDEP: challenges and future directions

R Whitney, S Sharma, KC Jones… - … : European Journal of …, 2023 - Elsevier
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related
deaths in children and adults with epilepsy. The incidence of SUDEP in children and adults …

Sudden unexpected death in epilepsy

GF Buchanan, ATN Maciel… - Current opinion in …, 2023 - journals.lww.com
Sudden unexpected death in epilepsy : Current Opinion in Neurology Sudden unexpected
death in epilepsy : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …

Proteomic alterations and novel markers of neurotoxic reactive astrocytes in human induced pluripotent stem cell models

D Labib, Z Wang, P Prakash, M Zimmer… - Frontiers in Molecular …, 2022 - frontiersin.org
Astrocytes respond to injury, infection, and inflammation in the central nervous system by
acquiring reactive states in which they may become dysfunctional and contribute to disease …

Differences in the cerebral amyloid angiopathy proteome in Alzheimer's disease and mild cognitive impairment

D Leitner, T Kavanagh, E Kanshin, K Balcomb… - Acta …, 2024 - Springer
Cerebral amyloid angiopathy (CAA) is characterized by amyloid beta (Aβ) deposition in
cerebrovasculature. It is prevalent with aging and Alzheimer's disease (AD), associated with …

Pilot study evaluating everolimus molecular mechanisms in tuberous sclerosis complex and focal cortical dysplasia

DF Leitner, E Kanshin, M Askenazi, Y Siu, D Friedman… - Plos one, 2022 - journals.plos.org
Background Tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs)
are associated with dysfunctional mTOR signaling, resulting in increased cell growth and …

Neuropathology findings in autonomic brain regions in SUDEP and future research directions

S Patodia, A Somani, M Thom - Autonomic Neuroscience, 2021 - Elsevier
Autonomic dysfunction is implicated from clinical, neuroimaging and experimental studies in
sudden and unexpected death in epilepsy (SUDEP). Neuropathological analysis in SUDEP …

Sudden unexpected death in epilepsy

D Friedman - Current Opinion in Neurology, 2022 - journals.lww.com
Sudden unexpected death in epilepsy : Current Opinion in Neurology Sudden unexpected
death in epilepsy : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …

Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP

S Patodia, A Somani, J Liu, A Cattaneo… - Brain …, 2022 - Wiley Online Library
Several lines of evidence link deficient serotonin function and SUDEP. Chronic treatment
with serotonin reuptake inhibitors (SRIs) reduces ictal central apnoea, a risk factor for …

Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood

DF Leitner, C William, A Faustin, M Askenazi… - Acta …, 2022 - Springer
Sudden unexplained death in childhood (SUDC) is death of a child over 1 year of age that is
unexplained after review of clinical history, circumstances of death, and complete autopsy …

Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients

DF Leitner, E Kanshin, A Faustin, M Thierry… - Frontiers in …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) and epilepsy are reciprocally related. Among sporadic
AD patients, clinical seizures occur in 10–22% and subclinical epileptiform abnormalities …