Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Cytochrome P450 enzymes and drug metabolism in humans
M Zhao, J Ma, M Li, Y Zhang, B Jiang, X Zhao… - International journal of …, 2021 - mdpi.com
Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …
A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma
Z Liu, Y Zhang, C Shi, X Zhou, K Xu, D Jiao… - Journal of Translational …, 2021 - Springer
Background The tumor immunological microenvironment (TIME) has a prominent impact on
prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by …
prognosis and immunotherapy. However, the heterogeneous TIME and the mechanisms by …
The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
Drug-metabolizing cytochrome P450 enzymes have multifarious influences on treatment outcomes
Y Song, C Li, G Liu, R Liu, Y Chen, W Li, Z Cao… - Clinical …, 2021 - Springer
Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …
THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC
Z Wen, Y Zhang, X Wang, Y Wu, J Mao, Q Li… - International Journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized
by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a …
by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a …
The multifarious link between cytochrome P450s and cancer
AM Alzahrani, P Rajendran - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an
important role in the metabolism of endogenous as well as exogenous substances …
important role in the metabolism of endogenous as well as exogenous substances …
CYP4F12 is a potential biomarker and inhibits cell migration of head and neck squamous cell carcinoma via EMT pathway
W Jia, S Chen, R Wei, X Yang, M Zhang, Y Qian… - Scientific Reports, 2023 - nature.com
Head and neck squamous cell carcinoma (HNSC) is the most common malignant tumor of
head and neck. Due to the insidious nature of HNSC and the lack of effective early …
head and neck. Due to the insidious nature of HNSC and the lack of effective early …
Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients
ZZ Chen, L Johnson, U Trahtemberg, A Baker, S Huq… - Clinical Proteomics, 2023 - Springer
Introduction Proteomic analysis of human plasma by LC–ESI–MS/MS has discovered a
limited number of new cellular protein biomarkers that may be confirmed by independent …
limited number of new cellular protein biomarkers that may be confirmed by independent …
Variation in expression of cytochrome P450 3A isoforms and toxicological effects: endo-and exogenous substances as regulatory factors and substrates
C Fujino, S Sanoh, T Katsura - Biological and Pharmaceutical …, 2021 - jstage.jst.go.jp
The CYP3A subfamily, which includes isoforms CYP3A4, CYP3A5, and CYP3A7 in humans,
plays important roles in the metabolism of various endogenous and exogenous substances …
plays important roles in the metabolism of various endogenous and exogenous substances …