Effective interventions and treatments for complex diseases have been implemented
globally, however, coverage in Africa has been comparatively lower due to lack of capacity …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is a blood disease caused by a single nucleotide substitution (T>
A) in the beta globin gene on chromosome 11. The single point mutation (Glu6Val) promotes …

Drug metabolizing enzymes play a crucial role in the pharmacokinetics and
pharmacodynamics of therapeutic drugs, influencing their efficacy and safety. This review …

Over 20 years after the introduction of angiotensin-converting enzyme inhibitors and
angiotensin receptor blockers, CKD remains a major public health burden with limited …

Sickle cell disease (SCD) is a monogenic disorder caused by a single base mutation but
despite its apparent genetic simplicity, the clinical phenotype is hugely variable. In addition …

Background: Glutathione system plays an important role in the protection of cells and tissue
against damage from oxidative stress. Impairment of the glutathione system due to genetic …

Background Osteoporosis is a major complication of beta thalassemia major (TM). Increased
oxidative stress and its controlling genes were linked to osteoporosis. Ile105 Val variant is a …

Platelets play important roles in vascular health. Activation of platelet may contribute to
coagulation and inflammation. Evidence suggests circulating platelets are chronically …

Sickle cell disease (SCD), although a monogenic disease, exhibits a complex clinical
phenotype that hampers optimum patient stratification and disease management, especially …