The use of immune checkpoint inhibitors in oncology and the occurrence of AKI: where do we stand?

R Franzin, GS Netti, F Spadaccino, C Porta… - Frontiers in …, 2020 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have
improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small …

Inflammation in kidney repair: Mechanism and therapeutic potential

Y Fu, Y Xiang, H Li, A Chen, Z Dong - Pharmacology & therapeutics, 2022 - Elsevier
The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when
injury is severe or persistent, the repair is incomplete or maladaptive and may lead to …

[HTML][HTML] Gut microbiota dysbiosis in AKI to CKD transition

GR Saranya, P Viswanathan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Background and aim The symptoms of acute kidney injury (AKI) include a sudden drop-in
glomerular filtration rate (GFR), a rise in serum creatinine (sCr), blood urea nitrogen (BUN) …

COVID-19. Pandemic surgery guidance

BLDM Brücher, G Nigri, A Tinelli, J Florencio… - 4 OPEN, 2020 - iris.uniroma1.it
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury

P Mehrotra, M Sturek, JA Neyra… - The Journal of clinical …, 2019 - Am Soc Clin Investig
We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates
in the activation of Th17 cells and influences renal injury. In rats, following renal …

Lymphocytes: versatile participants in acute kidney injury and progression to chronic kidney disease

C Cao, Y Yao, R Zeng - Frontiers in Physiology, 2021 - frontiersin.org
Background: Acute kidney injury (AKI) remains a major global public health concern due to
its high morbidity and mortality. The progression from AKI to chronic kidney disease (CKD) …

ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway

Y Cao, W Huang, F Wu, J Shang, F Ping, W Wang… - Cell Death & …, 2021 - nature.com
Acute lung injury induced by ischemia–reperfusion (I/R)-associated pulmonary inflammation
is associated with high rates of morbidity. Despite advances in the clinical management of …

Toxicity profile of combined immune checkpoint inhibitors and thoracic radiotherapy in esophageal cancer: A meta-analysis and systematic review

T Xu, Y Liu, X Lu, J Liang - Frontiers in Immunology, 2022 - frontiersin.org
Background Therapies based on the combination of immune checkpoint inhibitors (ICIs) and
thoracic radiotherapy (TRT) are transforming the treatment landscape of esophageal cancer …

Radiation recall pneumonitis induced by PD-1/PD-L1 blockades: mechanisms and therapeutic implications

F Teng, M Li, J Yu - BMC medicine, 2020 - Springer
Background The synergistic effect of radiotherapy (RT) in combination with immunotherapy
has been shown in several clinical trials and case reports. The overlapping pulmonary …

IFN‐γ+IL‐17+Th17 cells regulate fibrosis through secreting IL‐21 in systemic scleroderma

X Xing, A Li, H Tan, Y Zhou - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
This study aimed to explore the function of IFN‐γ+ IL‐17+ Th17 cells on fibrosis in systemic
scleroderma (SSc). Blood and skin samples were collected from 20 SSc cases and 10 …