Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Background Senescent cells, which can release factors that cause inflammation and
dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with …

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …

The skin is the largest organ and has a key protective role. Similar to any other tissue, the
skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

The senescence-associated secretory phenotype (SASP) defines the ability of senescent
cells to express and secrete a variety of extracellular modulators that includes cytokines …