Developments in managing CF continue to drive dramatic improvements in survival. As
newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of …

The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

Background Fungal infections are responsible for> 1.5 million deaths globally per year,
primarily in those with compromised immune function. This is concerning as the number of …

The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

Specialised CF care has led to a dramatic improvement in survival in CF: in the last four
decades, well above what was seen in the general population over the same period. With …

The human body is home to a complex and diverse microbial ecosystem that plays a central
role in host health. This includes a diversity of fungal species that is collectively referred to …

Fungi and bacteria encounter each other in various niches of the human body. There, they
interact directly with one another or indirectly via the host response. In both cases …

Neutrophilic inflammation has a key role in the pathophysiology of multiple chronic lung
diseases. The formation of neutrophil extracellular traps (NETs) has emerged as a key …

The lung microbiome, which is believed to be stable or at least transient in healthy people, is
now considered as a poly-microorganism component contributing to disease pathogenesis …

SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …