Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

Fine particle fraction (FPF) is defined in general terms as the fraction or percentage of the
drug mass contained in an aerosol cloud that may be small enough to enter the lungs and …

Background: A validated method to predict lung deposition for inhaled medication from in
vitro data is lacking in spite of many attempts to correlate in vitro and in vivo outcomes. By …

Despite the prevalence of inhalation therapy in the treatment of pediatric respiratory
disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for …

Anatomical and physiological changes alter airflow characteristics and aerosol distribution
in the developing lung. Correlation between age and aerosol dosimetry is needed …

The airway of pediatric patients' changes through development, presenting a challenge in
developing pediatric-specific aerosol therapeutics. Our work aims to quantify geometric …

Effective pulmonary drug delivery through pressurized-metered dose inhalers (pMDIs)
depends on accurately targeting pharmaceutical aerosols to specific lung areas. Achieving …

While dry powder aerosol formulations offer a number of advantages, their use in children is
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …

The upper airways of children undergo developmental changes around age 6, yielding
differences between adult and pediatric anatomies. These differences include the cricoid …

Purpose In the present work, a comparison between MDI and DPI for evaluating
performance of the devices were carried out by experimentally investigating the deposition …