[HTML][HTML] A systematic review of computational approaches to understand cancer biology for informed drug repurposing

F Ahmed, A Samantasinghar, AM Soomro, S Kim… - Journal of Biomedical …, 2023 - Elsevier
Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

PseUdeep: RNA pseudouridine site identification with deep learning algorithm

J Zhuang, D Liu, M Lin, W Qiu, J Liu, S Chen - Frontiers in Genetics, 2021 - frontiersin.org
Background: Pseudouridine (Ψ) is a common ribonucleotide modification that plays a
significant role in many biological processes. The identification of Ψ modification sites is of …

Predicting breast cancer recurrence and metastasis risk by integrating color and texture features of histopathological images and machine learning technologies

X Liu, P Yuan, R Li, D Zhang, J An, J Ju, C Liu… - Computers in biology …, 2022 - Elsevier
Abstract About 30%–40% breast cancer patients suffer from recurrence and metastasis,
even after targeted therapy like trastuzumab. Since breast cancer recurrence and metastasis …

DGHNE: network enhancement-based method in identifying disease-causing genes through a heterogeneous biomedical network

B He, K Wang, J Xiang, P Bing, M Tang… - Briefings in …, 2022 - academic.oup.com
The identification of disease-causing genes is critical for mechanistic understanding of
disease etiology and clinical manipulation in disease prevention and treatment. Yet the …

AAAKB: A manually curated database for tracking and predicting genes of Abdominal aortic aneurysm (AAA)

D Yao, S Mei, W Tang, X Xu, Q Lu, Z Shi - PLoS One, 2023 - journals.plos.org
Abdominal aortic aneurysm (AAA), an extremely dangerous vascular disease with high
mortality, causes massive internal bleeding due to aneurysm rupture. To boost the research …

HAUS5 is a potential prognostic biomarker with functional significance in breast cancer

Z Huang, J Yang, W Qiu, J Huang, Z Chen… - Frontiers in …, 2022 - frontiersin.org
Background Breast cancer (BRCA) has become the most frequently appearing, lethal, and
aggressive cancer with increasing morbidity and mortality. Previously, it was discovered that …

A bioinformatics framework to identify the biomarkers and potential drugs for the treatment of colorectal cancer

X Leng, J Yang, T Liu, C Zhao, Z Cao, C Li, J Sun… - Frontiers in …, 2022 - frontiersin.org
Colorectal cancer (CRC), a common malignant tumor, is one of the main causes of death in
cancer patients in the world. Therefore, it is critical to understand the molecular mechanism …

PICALM as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltration in Breast Cancer

P Lyu, Y Yu, M Liu, S Cheng, M Chen, Y Liu… - Applied Biochemistry and …, 2024 - Springer
PICALM (phosphatidylinositol-binding clathrin assembly protein) mutations have been
linked to a number of human disorders, including leukemia, Alzheimer's disease, and …

LncRNA KRT19P3 is involved in breast cancer cell proliferation, migration and invasion

Y Fan, X Dong, M Li, P Liu, J Zheng, H Li… - Frontiers in …, 2022 - frontiersin.org
Long non-coding RNAs (LncRNAs) have already been taken as critical regulatory molecules
in breast carcinoma (BC). Besides, the progression of BC is closely associated with the …

Drug repositioning for SARS-CoV-2 by Gaussian kernel similarity bilinear matrix factorization

Y Wang, J Xiang, C Liu, M Tang, R Hou… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is currently spreading rapidly around the world …