Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

Albumin is the main protein of blood plasma, lymph, cerebrospinal and interstitial fluid. The
protein participates in a variety of important biological functions, such as maintenance of …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

This review gives an overview of clinical characteristics, treatment and outcome of nutritional
and acquired cobalamin (Cbl; synonym: vitamin B12) deficiencies, inborn errors of Cbl …

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been
highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular …

Severe vitamin D deficiency (reduction in serum 25 (OH) D concentration) in infants and
children can cause features of the Fanconi syndrome, including phosphaturia, glycosuria …

Nine compounds are classified as water-soluble vitamins, eight B vitamins and one vitamin
C. The vitamins are mandatory for the function of numerous enzymes and lack of one or …

Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal
convoluted tubule cells are the production site of 1α, 25-dihydroxyvitamin D3. Patients with …

The vertebrate endocytic receptor CUBAM, consisting of three cubilin monomers complexed
with a single amnionless molecule, plays a major role in protein reabsorption in the renal …

Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic
development and adult tissue homeostasis. Loss of this receptor in congenital or acquired …