The physicochemical nature of DNA allows the assembly of highly predictable structures via
several fabrication strategies, which have been applied to make breakthroughs in various …

Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Nucleic acids are considered as perfect programmable materials for cascade signal
amplification and not merely as genetic information carriers. Among them, catalytic hairpin …

CRISPR-based diagnostics (CRISPR-Dx) has shown great promise in molecular
diagnostics, but its utility in the sensing of microRNA (miRNA) biomarkers is limited by …

In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …

Enzyme-free amplification techniques based on dynamic DNA self-assembly (DDSA) have
recently been developed for the in situ detection of mRNA in living cells. However, signal …

Catalytic hairpin assembly (CHA) with advantages of high efficiency, flexible design, and
mild reaction condition is considered a promising molecular amplifier. Modified working …

Owing to its important physiological functions, especially as molecular biomarkers of
diseases, RNA is an important focus of biomedicine and biochemical sensing. Signal …

Isothermal, enzyme-free amplification techniques, such as the hybridization chain reaction
(HCR) and catalytic hairpin assembly (CHA), have gained increasing attention for miRNA …

DNA has become a promising material to construct high-order structures and molecular
devices owing to its sequence programmability. Herein, a DNA machine based on branched …