Biopharmaceuticals have allowed the control of previously untreatable diseases. However,
their low solubility and stability still hinder their application, transport, and storage. Hence …

RNA molecules have a variety of cellular functions that can drive disease pathologies. They
are without a doubt one of the most intriguing yet controversial small-molecule drug targets …

Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-
associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive …

Messenger RNAs (mRNAs) with phosphorothioate modification (PS‐mRNA) to the
phosphate site of A, G, C, and U with all 16 possible combinations were prepared, and the …

Myotonic dystrophy type 1 (DM1) is a life-threatening and chronically debilitating
neuromuscular disease caused by the expansion of a CTG trinucleotide repeat in the 3 …

Rapid development within the fields of both fragment‐based drug discovery (FBDD) and
medicinal targeting of RNA provides possibilities for combining technologies and methods in …

Native electrospray ionization (ESI) and nanoelectrospray ionization (nESI) allow
researchers to analyze intact biomolecules and their complexes by mass spectrometry (MS) …

The rapidly accelerating characterization of RNA tertiary structures has revealed their
pervasiveness and active roles in human diseases. Small molecule-mediated modulation of …

Microscale Thermophoresis (MST) is a powerful biophysical technique that measures the
mobility of biomolecules in response to a temperature gradient, making it useful for …

RNA is a biopolymer of high relevance in the biopharmaceuticals field and in fundamental
and applied research; however, preservation of RNA stability is still a remarkable challenge …