Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing
evidence has shown that reprogrammed metabolism may play a critical role in the …

Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial
oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the …

Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …

Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …

Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha
(PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor …

Metabolic reprogramming provides tumors with an energy source and biofuel to support
their survival in the malignant microenvironment. Extensive research into the intrinsic …

Background Alterations in metabolism are one of the emerging hallmarks of cancer cells and
targeting dysregulated cancer metabolism provides a new approach to developing more …

Metformin has been used to treat type 2 diabetes for over 50 years. Epidemiological,
preclinical and clinical studies suggest that metformin treatment reduces cancer incidence in …

During malignant progression cancer cells undergo a series of changes, which promote
their survival, invasiveness and metastatic process. One of them is a change in glucose …

Background Pyruvate dehydrogenase complex (PDC) plays a central role in carbohydrate
metabolism, linking cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) …