Mechanisms and functions of nuclear envelope remodelling
R Ungricht, U Kutay - Nature Reviews molecular cell biology, 2017 - nature.com
As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …
membrane shell for the genome and a versatile communication interface between the …
The nuclear envelope environment and its cancer connections
KH Chow, RE Factor, KS Ullman - Nature Reviews Cancer, 2012 - nature.com
Because of the association between aberrant nuclear structure and tumour grade, nuclear
morphology is an indispensible criterion in the current pathological assessment of cancer …
morphology is an indispensible criterion in the current pathological assessment of cancer …
A spontaneously blinking fluorophore based on intramolecular spirocyclization for live-cell super-resolution imaging
S Uno, M Kamiya, T Yoshihara, K Sugawara… - Nature …, 2014 - nature.com
Single-molecule localization microscopy is used to construct super-resolution images, but
generally requires prior intense laser irradiation and in some cases additives, such as thiols …
generally requires prior intense laser irradiation and in some cases additives, such as thiols …
Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II
Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …
they interplay remains unclear. To approach this issue, we investigated genome-wide …
Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30‐nm chromatin structure
How a long strand of genomic DNA is compacted into a mitotic chromosome remains one of
the basic questions in biology. The nucleosome fibre, in which DNA is wrapped around core …
the basic questions in biology. The nucleosome fibre, in which DNA is wrapped around core …
Nuclear membrane rupture and its consequences
J Maciejowski, EM Hatch - Annual review of cell and …, 2020 - annualreviews.org
The nuclear envelope is often depicted as a static barrier that regulates access between the
nucleus and the cytosol. However, recent research has identified many conditions in …
nucleus and the cytosol. However, recent research has identified many conditions in …
The nuclear pore complex: birth, life, and death of a cellular behemoth
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …
1, 6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
Liquid droplets formed inside the cell by liquid–liquid phase separation maintain membrane-
less condensates/bodies (or compartments). These droplets are important for concentrating …
less condensates/bodies (or compartments). These droplets are important for concentrating …
Functional architecture of the nuclear pore complex
E Grossman, O Medalia… - Annual review of …, 2012 - annualreviews.org
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the
cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous …
cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous …
A transient rise in free Mg2+ ions released from ATP-Mg hydrolysis contributes to mitotic chromosome condensation
For cell division, negatively charged chromatin, in which nucleosome fibers (10 nm fibers)
are irregularly folded [1–5], must be condensed into chromosomes and segregated. While …
are irregularly folded [1–5], must be condensed into chromosomes and segregated. While …