Regulated cell death pathways in kidney disease

AB Sanz, MD Sanchez-Niño, AM Ramos… - Nature Reviews …, 2023 - nature.com
Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Heme proteins and kidney injury: beyond rhabdomyolysis

KA Nath, RD Singh, AJ Croatt, CM Adams - Kidney360, 2022 - journals.lww.com
Heme proteins, the stuff of life, represent an ingenious biologic strategy that capitalizes on
the biochemical versatility of heme, and yet is one that avoids the inherent risks to cellular …

Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury

A Lau, JJ Rahn, M Chappellaz, H Chung… - Science …, 2022 - science.org
The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood.
Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on …

A polymeric nanosponge as a broad-spectrum reactive oxygen species scavenger for acute kidney injury treatment

S He, C Chen, F Li, W Xu, D Li, M Liang, X Yang - Nano Letters, 2023 - ACS Publications
Acute kidney injury (AKI) is closely associated with the overproduction of reactive oxygen
species (ROS), which can cause multiple organ dysfunctions without timely treatment …

Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke

Y Luan, E Huang, J Huang, Z Yang, Z Zhou… - Journal of translational …, 2023 - degruyter.com
Abstract Background and Objectives Myoglobin released by rhabdomyolysis (RM) is
considered to be involved in pathogenesis of kidney disease caused by crush injury, but …

Molecular mechanisms of rhabdomyolysis-induced kidney injury: from bench to bedside

JF Hebert, KG Burfeind, D Malinoski… - Kidney International …, 2023 - Elsevier
Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the
muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites …

[HTML][HTML] Nanotherapeutic kidney cell-specific targeting to ameliorate acute kidney injury

Y Funahashi, SH Park, JF Hebert, MB Eiwaz… - Kidney International, 2024 - Elsevier
Acute kidney injury (AKI) increases the risk of in-hospital death, adds to expense of care,
and risk of early chronic kidney disease. AKI often follows an acute event such that timely …

Wasp venom-induced acute kidney injury: current progress and prospects

F Yu, L Wang, H Yuan, Z Gao, L He, F Hu - Renal Failure, 2023 - Taylor & Francis
Wasp venom can trigger local and systemic reactions, with the kidneys being commonly
affected, potentially causing acute kidney injury (AKI). Despite of the recent advances, our …

Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules

S Matsui, T Yamamoto, Y Takabatake, A Takahashi… - Autophagy, 2024 - Taylor & Francis
The renoprotective effects of SLC5A2/SGLT2 (solute carrier 5 (sodium/glucose
cotransporter), member 2) inhibitors have recently been demonstrated in non-diabetic …

[HTML][HTML] A novel small molecule Hsp90 inhibitor, C-316-1, attenuates acute kidney injury by suppressing RIPK1-mediated inflammation and necroptosis

X Liu, M Liu, L Jiang, L Gao, Y Zhang, Y Huang… - International …, 2022 - Elsevier
Acute kidney injury (AKI) is marked by a fast deterioration of the kidney function that may be
caused by a variety of factors. Recently, although our group found that PPBICA alleviated …