Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are two homologous transcriptional coactivators that promote cell proliferation, stem cell …

ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …

G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction
upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT …

The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue
homeostasis, and their dysregulation contributes to human cancer. Here, we discover …