Background: It is widely accepted that the adenoma–carcinoma sequence represents the
process by which most, if not all, colorectal cancers arise. The evidence supporting this …

Colorectal cancer affected approximately 135,000 people in the United States in 2001,
resulting in 57,000 deaths. Colorectal cancer develops as the result of the progressive …

Primary culture of the cancer cells from patients' tumors can provide crucial information of
individual tumors, yet the technology has not been optimized until now. We developed an …

The tumor suppressor gene product p53 plays an important role in the cellular response to
DNA damage. DNA damage can lead to p53‐mediated growth arrest and apoptosis. High …

We describe and discuss a method of protein extraction for Western blot analysis from
formalin-fixed, paraffin-embedded tissue sections. From 5-mm2 50-μm-thick tissue sections …

BACKGROUND Anthranoid laxatives are the most commonly used purgatives in the therapy
of acute and chronic constipation. Recent experimental data and a prospective cohort study …

BACKGROUND & AIMS: According to the somatic mutation theory, monoclonal colorectal
lesions arise from sequential mutations in the progeny of a single stem cell. However …

Microallelotyping of many regions from individual colorectal tumours was used to determine
the sequence and tempo of alleiic loss on 5q, 17p and 18q during neoplastic progression …

Colorectal carcinogenesis is widely accepted as one of the best‐characterized examples of
stepwise progression. The existing colorectal carcinogenesis model assumes genetic …

A colorectal polyp is defined as a mass that protrudes into the lumen of the colon. The
clinical significance of polyps is defined by their histologic classification. The main distinction …