Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …

Respiratory substrates and adenine nucleotides cross the mitochondrial outer membrane
through the voltage-dependent anion channel (VDAC), comprising three isoforms—VDAC1 …

Cancer metabolism is emerging as a chemotherapeutic target. Enhanced glycolysis and
suppression of mitochondrial metabolism characterize the Warburg phenotype in cancer …

This review presents current knowledge related to VDAC1 as a multi-functional
mitochondrial protein acting on both sides of the coin, regulating cell life and death, and …

Formation of the mitochondrial membrane potential (ΔΨ) depends on flux of respiratory
substrates, ATP, ADP, and Pi through voltage-dependent anion channels (VDAC). As tubulin …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate
(ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the …

As the voltage-dependent anion channel (VDAC) forms the interface between mitochondria
and the cytosol, its importance in metabolism is well understood. However, research on …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …