Estrogens exert a wide variety of effects on growth, development, and differentiation,
including important regulatory functions within the reproductive systems of both females and …

As early as the 1800s, the actions of estrogen have been implicated in the development and
progression of breast cancer. The estrogen receptor (ER) was identified in the late 1950s …

The human estrogen receptor α (ERα) and the recently identified ERβ share a high degree
of amino acid homology; however, there are significant differences in regions of these …

Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating
and reducing breast cancer progression in ER-positive disease. However, resistance to …

LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in
fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single …

The tumor necrosis factor-α (TNF-α) promoter was used to explore the molecular
mechanisms of estradiol (E2)-dependent repression of gene transcription. E2 inhibited basal …

The effects of estrogens, particularly 17β-estradiol (E2), are mediated by estrogen receptor α
(ERα) and ERβ. Upon binding to E2, ERs homo-and heterodimerize when coexpressed. The …

Ligands for the estrogen receptor (ER) that have the capacity to selectively bind to or
activate the ER subtypes ERα or ERβ would be useful in elucidating the biology of these two …

Synthetic estrogen receptor ligands such as tamoxifen and raloxifene produce biologic
responses which can be either estrogenic or anti-estrogenic, depending upon the tissue in …

Receptor-interacting protein 140 (RIP140) encodes a histone deacetylase (HDAC) inhibitor-
sensitive repressive activity. Direct interaction of RIP140 with HDAC1 and HDAC3 occurs in …