Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies

GR Gandhi, ABS Vasconcelos, DT Wu, HB Li… - Nutrients, 2020 - mdpi.com
The consumption of plant-based food is important for health promotion, especially
concerning the prevention and management of chronic diseases. Flavonoids are the main …

Potential and therapeutic roles of diosmin in human diseases

E Huwait, M Mobashir - Biomedicines, 2022 - mdpi.com
Because of their medicinal characteristics, effectiveness, and importance, plant-derived
flavonoids have been a possible subject of research for many years, particularly in the last …

Metabolism and pharmacological activities of the natural health-benefiting compound diosmin

Y Zheng, R Zhang, W Shi, L Li, H Liu, Z Chen, L Wu - Food & function, 2020 - pubs.rsc.org
Diosmin is a famous natural flavonoid for treating chronic venous insufficiency and varicose
veins. Recently, extensive study has indicated that diosmin possesses diverse …

Potential therapeutic anti-inflammatory and immunomodulatory effects of dihydroflavones, flavones, and flavonols

C Zaragozá, L Villaescusa, J Monserrat, F Zaragozá… - Molecules, 2020 - mdpi.com
Systemic inflammation, circulating immune cell activation, and endothelial cell damage play
a critical role in vascular pathogenesis. Flavonoids have shown anti-inflammatory effects. In …

The benefits of flavonoids in diabetic retinopathy

AL Matos, DF Bruno, AF Ambrósio, PF Santos - Nutrients, 2020 - mdpi.com
Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading
cause of legal blindness among adults of working age in developed countries. After 20 years …

[HTML][HTML] Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids

C Zaragozá, J Monserrat, C Mantecon… - Biomedicine & …, 2021 - Elsevier
Platelets exert an essential role in vascular inflammation and thrombosis. Flavonoids are
natural compounds employed for the clinical management of vascular disorders preventing …

Modulatory effect of diosmin and diosmetin on metalloproteinase activity and inflammatory mediators in human skin fibroblasts treated with lipopolysaccharide

M Feldo, M Wójciak, A Ziemlewska, S Dresler, I Sowa - Molecules, 2022 - mdpi.com
Diosmin is widely used as a venoactive drug in the pharmacological treatment of chronic
venous disorders. It exerts a strong protective effect on blood vessels via an increase in the …

[HTML][HTML] A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

OD Frenț, L Stefan, CM Morgovan… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The main goal of this systematic review on the flavonol class secondary metabolite quercetin
is to evaluate and summarize the existing research on quercetin's potential health benefits …

Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species

QW Wu, M Wei, LF Feng, L Ding, WK Wei… - Plant …, 2022 - academic.oup.com
Abstract Linarin (acacetin-7-O-rutinoside), isorhoifolin (apigenin-7-O-rutinoside), and
diosmin (diosmetin-7-O-rutinoside) are chemically and structurally similar flavone rutinoside …

[HTML][HTML] Plant metabolite diosmin as the therapeutic agent in human diseases

S Mustafa, M Akbar, MA Khan, K Sunita… - Current research in …, 2022 - Elsevier
Plant-derived flavonoids have been the focus of research for many years mainly in the last
decade owing to their therapeutic properties. So far, about 4000 flavonoids have been …