The endoplasmic reticulum (ER) is a cellular organelle where secretory and membrane
proteins, as well as lipids, are synthesized and modified. When cells are subjected to ER …

Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC)
generation is of particular importance for current hematopoietic regenerative approaches …

Abstract Changes in cell fate and identity are essential for endothelial-to-haematopoietic
transition (EHT), an embryonic process that generates the first adult populations of …

Platelets play critical roles in hemostasis and thrombosis. Emerging evidence indicates that
they are versatile cells and also involved in many other physiological processes and …

Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic
arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify …

Despite progress in identifying the cellular composition of hematopoietic stem/progenitor cell
(HSPC) niches, little is known about the molecular requirements of HSPC support. To …

During ontogeny, the transcription factor RUNX1 governs the emergence of definitive
hematopoietic cells from specialized endothelial cells called hemogenic endothelium (HE) …

Rationale: Collagen-and calcium-binding EGF domain–containing protein 1 (CCBE1) is
essential for lymphangiogenesis in vertebrates and has been associated with Hennekam …

The bone marrow (BM) microenvironment provides critical physical cues for hematopoietic
stem and progenitor cell (HSPC) maintenance and fate decision mediated by cell-matrix …

Microenvironment and activation signals likely imprint heterogeneity in the lymphatic
endothelial cell (LEC) population. Particularly LECs of secondary lymphoid organs are …