Sperm motility is linked to the activation of signaling pathways that trigger movement. These
pathways are mainly dependent on Ca2+, which acts as a secondary messenger. The …

Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000
sperm out of millions in an ejaculate reach the fallopian tube and thus have a chance of …

BACKGROUND Intensive research on sperm ion channels has identified members of
several ion channel families in both mouse and human sperm. Gene knock-out studies have …

Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome
reaction (AR), three processes necessary for successful fertilization. The AR enables the …

An aging world population exposed to a sedentary life style is currently plagued by chronic
metabolic diseases, such as type-2 diabetes, that are spreading worldwide at an …

Marijuana is the most widely consumed recreational drug worldwide, which raises concerns
for its potential effects on fertility. Many aspects of human male reproduction can be …

Ion channels control the ability of human sperm to fertilize the egg by triggering
hyperactivated motility, which is regulated by membrane potential, intracellular pH, and …

In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …

Sperm are guided through the female reproductive tract. A temperature difference of about
2° C exists between the storage site and fertilization site of the mammalian oviduct, leading …

The transient receptor protein vanilloid channels, TRPV1 and TRPV4, have recently been
shown to be mechanosensors in the ocular lens that act to transduce physical changes in …