The present account surveys the results of the plethora of works on Nmethylation of nitrogen-
containing substrates, mainly amines. The countless reports in the literature on this issue …

We herein report the use of phenyl trimethylammonium iodide (PhMe3NI) as a safe,
nontoxic, and easy-to-handle reagent for an absolutely monoselective N-methylation of …

This review provides a comprehensive overview of mono‐alkylation methodologies
targeting crucial nitrogen moieties–amines, amides, and sulfonamides–found in organic …

Described herein is a simple, novel, one-pot acylamination reaction of unactivated alcohols.
This reaction employs the combination of PCl3 and triflic anhydride (Tf2O) or copper triflate …

A highly-efficient and practical method for S-alkylation of arylthioureas was reported. Using
tetraalkylammonium salts as alkylation reagents, a series of 68 S-substituted aryl …

Tandem conversion of aldoximes to N‐methylated amides with methanol in presence of a
single Ru (II) catalyst is accomplished through the Ru (II)‐mediated rearrangement followed …

We described here a simple and metal‐free protocol to synthesize [1, 2, 3] triazolo [1, 5‐a]
quinoline 3‐carboxamides through a two‐step synthetic strategy, in which the first step uses …

Bimolecular nucleophilic substitution (SN 2) is one of the most well-known fundamental
reactions in organic chemistry to generate new molecules from two molecules. In principle, a …

Here we report on the use of formic acid as a green and safe reagent for the N‐methylation
of primary amides in the presence of a Pd/In2O3 solid catalyst. No additive is needed and …

The N-methylation of primary carboxamides is based on two consecutive reactions. The
silylation of the corresponding carboxamides with chloro (chloromethyl) dimethylsilane in …