Objectives Solid-state transformations may occur during any stage of pharmaceutical
processing and upon storage of a solid dosage form. Early detection and quantification of …

Papers and patents that deal with polymorphism (crystal systems for which a substance can
exist in structures defined by different unit cells and where each of the forms has the same …

It is now just about 10 years since the publication of the first edition of Polymorphism in
Pharmaceutical Solids, which certainly received a positive reaction from workers in drug …

The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …

This review describes how best to select the appropriate packaging options for solid, oral
drug products based on both chemical and physical stability, with respect to moisture …

Molecular crystals are ubiquitous in a variety of industrial contexts, from foods to chemicals
and pharmaceuticals. The timely identification of different molecular crystal forms (and …

Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated
in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary …

The complex interplay of temperature and water activity (aw)/relative humidity (RH) on the
solid form stability and transformation pathways of three hydrates (HyA, HyB, and HyC), an …

Physical characterization of solid form of drug is of paramount importance as its
biopharmaceutical properties and/or its processing behavior may be altered. Early …

Understanding the solid-state transitions of active pharmaceutical ingredients (APIs) is
essential for quality control since differences in their forms affect the bioavailability of APIs …