A survey of pairwise epistasis supports an outside-in hierarchy of clade-specifying and function-...

Epistasis and intramolecular networks in protein evolution

CM Miton, K Buda, N Tokuriki - Current opinion in structural biology, 2021 - Elsevier
Proteins are molecular machines composed of complex, highly connected amino acid
networks. Their functional optimization requires the reorganization of these intramolecular …
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