The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Platelet derived growth factor (PDGF) signaling plays an important role in activated hepatic
stellate cells and portal fibroblast proliferation, chemotaxis, migration and cell survival …

Abstract Background & Aims Hepatocyte apoptosis, the hallmark of non‐alcoholic
steatohepatitis (NASH) contributes to liver injury and fibrosis. Although, both the intrinsic and …

SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is
frequently associated with excessive deposition of collagen and SPARC-null mice fail to …

Although clinical studies have identified scarring/fibrosis as significant risk factors for
lymphedema, the mechanisms by which lymphatic repair is impaired remain unknown …

SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin or BM-40) is
a widely expressed profibrotic protein with pleiotropic roles, which have been studied in a …

Fibrogenic progression of chronic liver disease, whatever the etiology, is characterized by
persistent chronic parenchymal injury, chronic activation of inflammatory response, and …

Aims Tissue inhibitor of metalloproteinases (TIMPs) can mediate myocardial remodelling,
hypertrophy, and fibrosis in heart disease. We investigated the impact of TIMP2 vs. TIMP3 …

Hepatic fibrosis and cirrhosis cause strong human suffering and necessitate a monetary
burden worldwide. Therefore, there is an urgent need for the development of therapies. Pre …

OBJECTIVE Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally
discovered in bone as osteonectin, is a mediator of collagen deposition and promotes …