Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

Conotoxins: chemistry and biology

AH Jin, M Muttenthaler, S Dutertre, SWA Himaya… - Chemical …, 2019 - ACS Publications
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution …

S Rosati, ETJ van den Bremer, J Schuurman… - MAbs, 2013 - Taylor & Francis
Here, we describe a fast, easy-to-use, and sensitive method to profile in-depth structural
micro-heterogeneity, including intricate N-glycosylation profiles, of monoclonal antibodies at …

Mollusc N-glycosylation: structures, functions and perspectives

E Staudacher - Biomolecules, 2021 - mdpi.com
Molluscs display a sophisticated N-glycan pattern on their proteins, which is, in terms of
involved structural features, even more diverse than that of vertebrates. This review …

Structural and functional analyses of cone snail toxins

H Morales Duque, S Campos Dias, OL Franco - Marine drugs, 2019 - mdpi.com
Cone snails are marine gastropod mollusks with one of the most powerful venoms in nature.
The toxins, named conotoxins, must act quickly on the cone snails´ prey due to the fact that …

Pharmacology of predatory and defensive venom peptides in cone snails

JR Prashanth, S Dutertre, RJ Lewis - Molecular biosystems, 2017 - pubs.rsc.org
Cone snails are predatory gastropods whose neurotoxic venom peptides (conotoxins) have
been extensively studied for pharmacological probes, venom evolution mechanisms and …

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus

SWA Himaya, AH Jin, S Dutertre… - Journal of Proteome …, 2015 - ACS Publications
Venomous marine cone snails produce a unique and remarkably diverse range of venom
peptides (conotoxins and conopeptides) that have proven to be invaluable as …

Multistep fractionation and mass spectrometry reveal zwitterionic and anionic modifications of the N-and O-glycans of a marine snail

B Eckmair, C Jin, D Abed-Navandi… - Molecular & Cellular …, 2016 - ASBMB
Various studies in the past have revealed that molluscs can produce a wide range of rather
complex N-glycan structures, which vary from those occurring in other invertebrate animals; …

Mucin-Type O-Glycosylation in Invertebrates

E Staudacher - Molecules, 2015 - mdpi.com
O-Glycosylation is one of the most important posttranslational modifications of proteins. It
takes part in protein conformation, protein sorting, developmental processes and the …

The complexity of glycoprotein-derived glycans

JFG Vliegenthart - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
A brief review is presented of our studies on the structure of glycoprotein-derived glycans.
The emphasis is on the introduction of high-resolution 1 H-NMR spectroscopy for the …