Synthetic product-based approach toward potential antileishmanial drug development
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …
(NTD) with no effective vaccines available. The available chemotherapeutics against …
The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis
Leishmaniasis is a parasitic disease and categorised as a neglected tropical disease (NTD).
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …
Synthetic and medicinal perspective of antileishmanial agents: an overview
S Pawar, MK Kumawat, M Kundu, K Kumar - Journal of Molecular Structure, 2023 - Elsevier
Leishmaniasis is one of the most common neglected tropical diseases (NTD), and is
originated in over 98 countries, affecting about 12 million people every year, which is …
originated in over 98 countries, affecting about 12 million people every year, which is …
Synthesis, antimalarial, antileishmanial evaluation, and molecular docking study of some 3-aryl-2-styryl substituted-4(3H)-quinazolinone derivatives
Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with
promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted …
promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted …
Pyridoxal kinase gene deletion leads to impaired growth, deranged redox metabolism and cell cycle arrest in Leishmania donovani
Pyridoxal kinase (PdxK) is a vitamin B 6 salvage pathway enzyme which produces pyridoxal
phosphate. We have investigated the impact of PdxK deletion in Leishmania donovani on …
phosphate. We have investigated the impact of PdxK deletion in Leishmania donovani on …
[HTML][HTML] Synthesis of Nitrostyrylthiazolidine-2, 4-dione Derivatives Displaying Antileishmanial Potential
O Khoumeri, S Hutter, N Primas, C Castera-Ducros… - Pharmaceuticals, 2024 - mdpi.com
A series of 61 thiazolidine-2, 4-diones bearing a styryl group at position 5 was synthesized
in 2–5 steps and their structure was proved by elemental and spectral analyses. The …
in 2–5 steps and their structure was proved by elemental and spectral analyses. The …