Abstract “In silico organisms” are computational genome-scale metabolic models used in
systems and synthetic biology developed by constraint-based metabolic simulations using …

Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak
antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically …

Secondary metabolites are not essential for the growth of microorganisms, but they play a
critical role in how microbes interact with their surroundings. In addition to this important …

Streptomyces clavuligerus (S. clavuligerus) is a filamentous Gram-positive bacterial
producer of the β-lactamase inhibitor clavulanic acid (CA). Antibiotics biosynthesis and …

13C metabolic flux analysis (MFA) has become an indispensable tool to measure metabolic
reaction rates (fluxes) in living organisms, having an increasingly diverse range of …

Clavulanic acid is a potent β-lactamase inhibitor produced by Streptomyces clavuligerus,
widely used in combination with β-lactam antibiotics to combat antimicrobial resistance. This …

Understanding the metabolism of Saccharopolyspora pogona on a global scale is essential
for manipulating its metabolic capabilities to improve butenyl-spinosyn biosynthesis. Here …

In the present study, Streptomyces rimosus was confronted with Streptomyces noursei,
Penicillium rubens, Aspergillus niger, Chaetomium globosum, or Mucor racemosus in two …

Streptomyces clavuligerus (S. clavuligerus) has been widely studied for its ability to produce
clavulanic acid (CA), a potent inhibitor of β-lactamase enzymes. In this study, S. clavuligerus …

Importance of the work: Clavulanic acid (CA) is a β-lactam antibiotic produced by
Streptomyces clavuligerus and is an inhibitor of β-lactamase enzymes responsible for …