This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …

Introduction Sickle cell disease (SCD) is a debilitating inherited disorder that affects millions
worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin …

4-Sulfanyl-substituted 1, 2, 3-triazoles were provided regioselectively with good yields and
broad scope via consecutive t-BuOK-promoted dephosphinylation of 1-phosphinyl-2 …

An orthogonal and regioselective synthesis of triazole disulfides in aqueous media under
mild conditions has been developed. This simple and practical approach is environment …

Abstract βcysteine 93 residue plays a key role in oxygen (O 2)-linked conformational
changes in the hemoglobin (Hb) molecule. This solvent accessible residue is also a target …

The sickle cell disease (SCD) has a genetic cause, characterized by a replacement of
glutamic acid to valine in the β-chain of hemoglobin. The disease has no effective treatment …

Allosteric effectors play an important role in regulating the oxygen supply efficiency of
hemoglobin for blood storage and disease treatment. However, allosteric effectors that are …

Sickle cell disease is the world's leading inherited genetic hemoglobinopathy, originating
from African peoples, characterized by the presence of more than 50% hemoglobin S in red …

Sickle cell disease (SCD) is the most common genetic disorder, affecting millions of people
worldwide. Aromatic aldehydes, which increase the oxygen affinity of human hemoglobin to …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin (Hb); approximately
300,000 babies are born worldwide with SCD each year. In SCD, fibers of polymerized …