Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …

Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of
medicines that directly reprogramme the central dogma of biology to prevent and treat …

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

The stealth effect plays a central role on capacitating nanomaterials for drug delivery
applications through improving the pharmacokinetics such as blood circulation …

In humans, lipid nanoparticles (LNPs) have safely delivered therapeutic RNA to hepatocytes
after systemic administration and to antigen-presenting cells after intramuscular injection …

During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

Conspectus mRNA drugs can preempt infectious disease and treat Mendelian disorders,
such as sickle cell anemia, muscular dystrophy, and cystic fibrosis, as well as autoimmunity …

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …