Tuberculosis (TB) drug discovery and development has undergone nothing short of a
revolution over the past 20 years. Successful public–private partnerships and sustained …

Cryptosporidiosis is a diarrheal disease caused by infection with Cryptosporidium spp.
parasites and is a leading cause of death in malnourished children worldwide. The only …

Cladosporin, a unique natural product from the fungus Cladosporium cladosporioides,
exhibits nanomolar inhibitory activity against Plasmodium falciparum by targeting its …

New oxazolidinones are in clinical development for the treatment of tuberculosis and
nontuberculous mycobacterial (NTM) infections, as a replacement for linezolid and tedizolid …

There is an urgent need for new tuberculosis (TB) treatments, with novel modes of action, to
reduce the incidence/mortality of TB and to combat resistance to current treatments. Through …

Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for
posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic …

Enzymes involved in rescuing stalled ribosomes and recycling translation machinery are
ubiquitous in bacteria and required for growth. Peptidyl tRNA drop-off is a type of abortive …

Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code,
serving as attractive drug targets. Within this family, the lysyl-tRNA synthetase (LysRS) …

In this study, a series of novel thieno [3, 2-b] pyridinone derivatives were designed and
synthesized using a scaffold hopping strategy. Six compounds showed potent anti …

Tuberculosis (TB) is the leading infectious disease caused by Mycobacterium tuberculosis
and the second-most contagious killer after COVID-19. The emergence of drug-resistant TB …