The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Diabetes mellitus is a metabolic disease caused by disorders of insulin secretion and
utilization. Long-term hyperglycemia, insulin resistance, and disorders of glucose and lipid …

A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …

Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders
of the kidney in various etiologies, which significantly affect human survival and social …

The biguanide metformin is the most commonly used antidiabetic drug. Recent studies show
that metformin not only improves chronic inflammation by improving metabolic parameters …

Metformin (dimethyl‐biguanide) can claim its origins in the use of Galega officinalis as a
plant treatment for symptoms ascribed to diabetes. Since the first clinical use of metformin as …

As a first-line treatment for diabetes, the insulin-sensitizing biguanide, metformin, regulates
glucose levels and positively affects cardiovascular function in patients with diabetes and …

Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules
and organelles in which accumulated autophagosomes do not fuse with lysosomes for …

Severe asthma is a difficult-to-treat chronic airway inflammatory disease requiring systemic
corticosteroids to achieve asthma control. It has recently been shown that drugs targeting …