Revolutionizing Synthetic Antibody Design: Harnessing Artificial Intelligence and Deep Sequencing Big Data for Unprecedented Advances
E Gallo - Molecular Biotechnology, 2024 - Springer
Synthetic antibodies (Abs) represent a category of engineered proteins meticulously crafted
to replicate the functions of their natural counterparts. Such Abs are generated in vitro …
to replicate the functions of their natural counterparts. Such Abs are generated in vitro …
[HTML][HTML] The Application of Machine Learning on Antibody Discovery and Optimization
J Zheng, Y Wang, Q Liang, L Cui, L Wang - Molecules, 2024 - mdpi.com
Antibodies play critical roles in modern medicine, serving as diagnostics and therapeutics
for various diseases due to their ability to specifically bind to target antigens. Traditional …
for various diseases due to their ability to specifically bind to target antigens. Traditional …
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter
optimization challenge known as “developability”, which reflects an antibody's ability to …
optimization challenge known as “developability”, which reflects an antibody's ability to …
Industrial Horizons in Pharmaceutical Science
The mission of industrial science in the pharmaceutical sector is to drive innovation in drug
development, delivery, and manufacturing, to fulfill unmet medical needs, and to provide …
development, delivery, and manufacturing, to fulfill unmet medical needs, and to provide …
AbLEF: antibody language ensemble fusion for thermodynamically empowered property predictions
Motivation Pre-trained protein language and/or structural models are often fine-tuned on
drug development properties (ie, developability properties) to accelerate drug discovery …
drug development properties (ie, developability properties) to accelerate drug discovery …
An Integrated Strategy to Identify Tyrosine Sulfation from the Therapeutic Proteins
E Jang, F Ma, D Tomazela… - Journal of the …, 2024 - ACS Publications
Posttranslational modifications (PTMs) are potential critical quality attributes in
biotherapeutic development, as they can affect drug efficacy and safety. Tyrosine sulfation …
biotherapeutic development, as they can affect drug efficacy and safety. Tyrosine sulfation …
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Designing effective monoclonal antibody (mAb) therapeutics face a significant challenge
known as" developability", which reflects an antibody's ability to progress through …
known as" developability", which reflects an antibody's ability to progress through …
Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies
X Yu, K Vangjeli, A Prakash, M Chhaya… - Antibody …, 2024 - academic.oup.com
Background Early assessment of antibody off-target binding is essential for mitigating
developability risks such as fast clearance, reduced efficacy, toxicity, and immunogenicity …
developability risks such as fast clearance, reduced efficacy, toxicity, and immunogenicity …
Cartography of the developability landscapes of native and human-engineered antibodies
Design: ing effective monoclonal antibody (mAb) therapeutics face a significant challenge
known as “developability”, which reflects an antibody's ability to progress through …
known as “developability”, which reflects an antibody's ability to progress through …
Hyperbox Mixture Regression for Process Performance Prediction in Antibody Production
This paper addresses the challenges of predicting bioprocess performance, particularly in
monoclonal antibody (mAb) production, where conventional statistical methods often fall …
monoclonal antibody (mAb) production, where conventional statistical methods often fall …