Abstract Background and Objective Nonlinear mixed-effect models (NLMEMs) are
increasingly used for the analysis of longitudinal studies during drug development. When …

Virtual bioequivalence trial (VBE) simulations based on (semi) mechanistic in vitro-in vivo
(IVIV) modeling have gained a huge interest in the pharmaceutical industry. Sophisticated …

Cytochrome P450 (CYP) enzymes play a central role in the elimination of approximately
80% of all clinically used drugs. Differences in CYP enzyme activity between individuals can …

We compared the powers of the likelihood ratio test (LRT) and the Pearson correlation test
(CT) from empirical Bayes estimates (EBEs) for various designs and shrinkages in the …

The beneficial health effects of fruits and vegetables have been attributed to their polyphenol
content. These compounds undergo many bioconversions in the body. Modeling polyphenol …

A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the
active species of the marine-derived preclinical histone deacetylase inhibitor, largazole …

Baclofen has been proposed for few years to help treating alcohol dependence at higher
doses than those used in neurology. Baclofen pharmacokinetics has been previously well …

Objective: Our previous studies substantiated that the biological activity of Schisandra
chinensis lignans during the treatment of Alzheimer's disease (AD) was mediated by …

This phase I, pilot clinical study was designed to evaluate the safety and the
pharmacokinetic (PK) profiles of the CIME (Metabolic Identity Card) combination of ten …

Our paper proposes a methodological strategy to select optimal sampling designs for
phenotyping studies including a cocktail of drugs. A cocktail approach is of high interest to …