Listeria monocytogenes—How This Pathogen Uses Its Virulence Mechanisms to Infect the Hosts

J Osek, K Wieczorek - Pathogens, 2022 - mdpi.com
Listeriosis is a serious food-borne illness, especially in susceptible populations, including
children, pregnant women, and elderlies. The disease can occur in two forms: non-invasive …

Genomic and pathogenicity islands of Listeria monocytogenes—overview of selected aspects

N Wiktorczyk-Kapischke, K Skowron… - Frontiers in Molecular …, 2023 - frontiersin.org
Listeria monocytogenes causes listeriosis, a disease characterized by a high mortality rate
(up to 30%). Since the pathogen is highly tolerant to changing conditions (high and low …

The host GTPase Dynamin 2 modulates apical junction structure to control cell-to-cell spread of Listeria monocytogenes

S Tijoriwalla, T Liyanage, TUB Herath, N Lee… - Infection and …, 2024 - journals.asm.org
The food-borne pathogen Listeria monocytogenes uses actin-based motility to generate
plasma membrane protrusions that mediate the spread of bacteria between host cells. In …

Build-a-bug workshop: using microbial-host interactions and synthetic biology tools to create cancer therapies

V Raman, CP Deshpande, S Khanduja, LM Howell… - Cell Host & Microbe, 2023 - cell.com
Many systemically administered cancer therapies exhibit dose-limiting toxicities that reduce
their effectiveness. To increase efficacy, bacterial delivery platforms have been developed …

Epigenetic-mediated antimicrobial resistance: Host versus pathogen epigenetic alterations

JS Muhammad, NA Khan, SK Maciver, AM Alharbi… - Antibiotics, 2022 - mdpi.com
Since the discovery of antibiotics, humans have been benefiting from them by decreasing
the morbidity and mortality associated with bacterial infections. However, in the past few …

Listeria monocytogenes co-opts the host exocyst complex to promote internalin A-mediated entry

GC Gyanwali, TUB Herath, A Gianfelice… - Infection and …, 2022 - Am Soc Microbiol
The bacterial pathogen Listeria monocytogenes induces its internalization (entry) into
intestinal epithelial cells through interaction of its surface protein, internalin A (InlA), with the …

Exploitation of the host exocyst complex by bacterial pathogens

K Ireton, GC Gyanwali, TUB Herath… - Molecular …, 2023 - Wiley Online Library
Intracellular bacterial pathogens remodel the plasma membrane of eukaryotic cells in order
to establish infection. A common and well‐studied mechanism of plasma membrane …

TMT-Based Quantitative Proteomic Analysis of Intestinal Organoids Infected by Listeria monocytogenes Strains with Different Virulence

C Zhou, Y Zou, J Huang, Z Zhao, Y Zhang… - International journal of …, 2022 - mdpi.com
L. monocytogenes, consisting of 13 serotypes, is an opportunistic food-borne pathogen that
causes different host reactions depending on its serotypes. In this study, highly toxic L …

Current methodologies available to evaluate the virulence potential among Listeria monocytogenes clonal complexes

M Sousa, R Magalhães, V Ferreira… - Frontiers in …, 2024 - frontiersin.org
Listeria monocytogenes is a foodborne pathogen that causes listeriosis in humans, the
severity of which depends on multiple factors, including intrinsic characteristics of the …

Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection

M Corre, V Boehm, V Besic, A Kurowska… - Nucleic Acids …, 2023 - academic.oup.com
Cell autonomous responses to intracellular bacteria largely depend on reorganization of
gene expression. To gain isoform-level resolution of these modes of regulation, we …