Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

DNA damage contributes to brain aging and neurodegenerative diseases. However, the
factors stimulating DNA repair to stave off functional decline remain obscure. We show that …

The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …

Base excision repair (BER) is an evolutionarily conserved process for maintaining genomic
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …

Normal term and spontaneous preterm births (PTB) are documented to be associated with
oxidative stress (OS), and imbalances in the redox system (balance between pro-and …

The six major mammalian DNA repair pathways were discovered as independent
processes, each dedicated to remove specific types of lesions, but the past two decades …

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …